Darragh Crosbie


“VISION”: in vivo tracking of limbal stem cells using mesoporous silica nanoparticles

Darragh studied in Trinity College Dublin in Ireland for both his undergraduate degree in Molecular Genetics and his PhD. During his PhD he looked at novel therapeutic targets for glaucoma and also developed viral vectors for delivery to the anterior chamber of the eye. Specifically, he was interested in lowering intraocular pressure and how the tight junctions of the aqueous humour outflow tissue play a role in both homeostasis and glaucomatous pathology. He began in MERLN in June and is now working on the regeneration of the corneal epithelium. The regulation of the corneal epithelium is interrupted in patients with limbal stem cell deficiency (LSCD), and are often treated with a limbal stem cell transplant. However, the mechanism of the long term re-epithelisation in these patients remains unknown. Darragh is investigating the migration of transplanted limbal stem cells to gain insight into the treatment effect, using mesoporous silica nanoparticles as a novel tracer.


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