Fredrik Wieland

PhD Student

The role of endothelial cells in the self-assembly of bioengineered islets.

With prior experience in the field of autoimmune diseases, such as systemic lupus erythematosus and type 1 diabetes mellitus, Fredrik started his PhD in the field of regenerative medicine in 2017. He aims to bring single cell techniques into regenerative medicine to study the spatial distribution of cells and how their organisation affects their function. His primary focus is to elucidate the role of endothelial cells in the self-assembly of the bioengineered islet. Bioengineered islets are composed of alpha and beta cells which together resemble part of the islets of Langerhans. Using them, he can study and develop a better understanding of the role of endothelial cells in the self-organisation of a heterogeneous cell population.

The research could not only result in new knowledge to improve the prospects of bioengineered islets in regenerative medicine but also improve current treatment of type 1 diabetes. Current treatment is islet transplantation, during the isolation procedure, cells rely on passive diffusion of nutrients until revascularisation is established and this causes a substantial cell loss.


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