Inorganic Nanomaterials for Regenerative Approaches

IBE Department

Inorganic Nanomaterials for Regenerative Approaches

Inorganic nanoparticles have unique physical properties and, in addition, are highly modifiable, making them versatile platforms for a range of medical applications including within regenerative medicine. This is a rapidly evolving field where their large diversity in terms of content, shape, modifications and morphology allows the development of new generations of biomaterials with changeable features at the nanoscale.  In our research we develop inorganic nanoparticles for different applications within regenerative medicine:

Research line 1: development of multimodal nanoparticles to trace (stem) cells.

In this work we develop multimodal imaging probes by combining several nanoparticles commonly used in bioimaging and drug delivery. This enables us to develop a flexible platform of multifunctional nanoparticles capable of tracking stem cells in the body while providing functional information at the (sub)cellular level. These results should enable critical information about the mechanisms of stem cell therapy and tissue regeneration. Part of this work is performed within a consortium (ZonMW grant) where we aim to develop multimodal nanoparticles for in vivo limbal epithelial stem cell tracking in the eye, in collaboration with the ophthalmology department.

Research line 2: using nanoparticles to create nanoparticle based films and organic-inorganic hybrid nanomaterials.

In this work we use inorganic nanoparticles as building blocks to create new types of 2D and 3D biomaterials. Such materials are especially well suited for the regeneration of harder tissues like bone or cartilage, as their properties allow for the formulation of harder and stiffer gels compared to purely organic systems. We can use the inorganic nanoparticles to design materials with important properties for tissue regeneration such as self-healing, cell responsive, injectable, controllable drug delivery and moldable properties. We are active within a large consortium (Materials driven regeneration, https://mdrresearch.nl/) to develop responsive and instructive biomaterials for bone and cartilage regeneration based on inorganic nanoparticles.

Selected publications

  • Roger Rosenbrand, David Barata, Pichaporn Sutthavas, Ronny Mohren, Berta Cillero-Pastor, Pamela Habibovic and Sabine van Rijt. Lipid surface modifications increase mesoporous silica nanoparticles labeling properties in mesenchymal stem cells. International journal of nanomedicine. Nov 20;13:7711-7725. 2018, https://doi.org/10.2147/IJN.S182428
  • Ziryan Othman, Berta Cillero Pastor, Sabine van Rijt, Pamela Habibovic. Understanding interactions between biomaterials and biological systems using proteomics. Biomaterials 2018 167:191-204, https://doi.org/10.1016/j.biomaterials.2018.03.020
  • Sabine van Rijt and Pamela Habibovic. Enhancing regenerative approaches with nanoparticles. Journal of the Royal Society Interface 2017 Apr; 14(129): 20170093, https://doi.org/10.1098/rsif.2017.0093
  • David Barata, Giulia Spennati, Cristina Correia, Nelson Ribeiro, Björn Harink, Clemens van Blitterswijk, Pamela Habibovic, Sabine van Rijt. Development of a shear stress-free microfluidic gradient generator capable of quantitatively analyzing single-cell morphology. Biomedical Microdevices. 2017, 19:81, https://doi.org/10.1007/s10544-017-0222-z
  • Sabine H. van Rijt, Deniz A. Bölükbas, Christian Argyo, Franziska Uhl, Gerald Burgstaller, Stefan Datz, Michael Lindner, Oliver Eickelberg, Melanie Königshoff, Thomas Bein, and Silke Meiners. Protease-mediated release of chemotherapeutics from mesoporous silica nanoparticles to ex vivo human and mouse lung tumors. ACSNano, 2015, 9(3), 2377-2389, https://doi.org/10.1021/nn5070343

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