Jasmin Dehnen

PhD Student

Gene editing therapy for corneal dystrophies.

Jasmin obtained her Bachelor’s and Master’s degree in Molecular Bioscience from Heidelberg University in Germany. During her studies, she specialized in molecular and cell biology. Among other projects, she worked towards modelling human brain development with stem cells and optimizing stem cell-based therapies. She did her Master’s thesis at the German Cancer Research Center where she studied base modifications in mRNA.

Following her passion for biology, she joined the cBITE Department in April 2020 in collaboration with the Ophthalmology Department at Maastricht UMC+ and Radboudumc. Her PhD project aims to apply CRISPR/Cas9 gene editing technologies for Fuchs endothelial corneal dystrophy. This degenerative eye disorder is characterized by the loss of corneal endothelial cells and eventually leads to impaired vision. Currently, the only treatment option for patients is corneal transplantation, which is greatly limited by the shortage of donor corneas. Exploring gene editing approaches for these patients will provide new insights into disease mechanisms of Fuchs dystrophy and can lay the foundation for advanced therapies.