Matilde Marradi

PhD Student

In silico multiscale models to simulate cell-ECM interactions and fibrotic tissue remodeling

Matilde is from Italy and she studied Biomedical Engineering at Politecnico di Milano. During her Masters’ she studied Biomechanics and Biomaterials, mainly focusing on computational modelling of biological processes. Matilde graduated with a thesis entitled "A patient-specific agent-based modeling framework of restenosis after balloon angioplasty in a superficial femoral artery - effects of mechanical damage and hemodynamics on cellular dynamics". In August 2023, she joined MERLN for her PhD work, within the framework of the Material Driven Regeneration (MDR) consortium. The aim of the project is to develop an in silico multiscale model of cell-substrate interaction within the onset of fibrosis. Fibrosis is a major cause of morbidity characterized by the excessive deposition of extra-cellular matrix (ECM) that causes irreversible loss of functionality to the tissue, eventually leading to organ failure. In silico models can help better understand the underlying mechanisms of this pathogenesis, allowing for further steps in the development of antifibrotic materials and treatments.

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