Virginie Joris


Reducing off-target populations in kidney organoids

With a PhD in Biomedical Sciences from the Université Catholique de Louvain in Belgium, Virginie started her postdoctoral research in the cBITE Department in January 2021. Her project is focused on reducing the off-target populations in iPSC-derived kidney organoids.Chronic kidney disease is widespread and increases all types of mortality. Renal transplantation is difficult due to the lack of donors and risks of immune rejection. New regenerative medicine–based strategies are needed, among which the in vitro development of kidney organoids from iPSC cells gives the opportunity to provide patient-specific solutions. The organoid differentiation protocols are well established but lead to the emergence of off-target populations such as neurons, muscle and cartilage. Virginie’s project focuses on reducing the off-target populations that seem to develop within the kidney organoids. Her work is part of the Regenerative Medicine Crossing Borders (RegMed XB) public–private partnership.


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